Nova will be at MIDD Summit 2026

Cristhyne Leon

Head of Scientific Support

novain silico

Since joining Nova in 2021, Cristhyne has been pivotal in advancing Model-Informed Drug Development by pairing robust mechanistic models with AI to enhance clinical trial predictions. As Scientific Project Lead and Head of Scientific Support, she oversees project portfolio excellence, mentors project managers, and helps sponsors maximize in silico approaches across drug development. Active in the global pharmacometrics community, Cristhyne serves on the leadership teams for ISoP's QSP Special Interest Group (QSP SIG) and is an active member of its Immunology & Inflammation Working Group.

Kyunghee Yang, PhD

Director of QSP, Clinical Pharmacology Modeling & Simulation Oncology

Dr. Kyunghee Yang leads the application of mechanistic modeling to support drug discovery and development across oncology programs at GSK. With more than 11 years of experience in model-informed drug development, she has extensive expertise in QSP, quantitative systems toxicology (QST), physiologically based pharmacokinetic (PBPK) modeling, and translational pharmacology. Prior to joining GSK, she held scientific and leadership roles at Simulations Plus, where she guided modeling strategies for both small molecules and biologics, led scientific teams, and directed industry collaborations focused on advancing mechanistic modeling approaches. Her work has contributed to regulatory submissions, clinical development decisions, and the advancement of QSP/QST methodologies through numerous publications and precompetitive collaborations. She received her Ph.D. in Pharmaceutical Sciences from the University of North Carolina at Chapel Hill, an M.S. in Pharmacokinetics, and a B.S. in Pharmacy from Seoul National University.